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The mechanism of action is known for some of them: pyrimethamine and dapsone inhibit dihydrofolate reductase, as does chlorguanide (proguanil) via its active metabolite. The sulfonamide sulfadoxine inhibits synthesis of dihydrofolic acid.
The method needs to be modified for ODTs as disintegration is required without water; thus the test should mimic disintegration in salivary contents. A modified dissolution apparatus is applied to an ODT with a disintegration time that is too fast to distinguish differences between tablets when the compendial method is used. |
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